As a business and alliance partner of Coriell, BioRep has access to more than a million vials of cells in liquid nitrogen. Cells that have been stored for nearly 50 years are still viable and available for research purposes today.

This is made possible by the techniques developed by Coriell staff to meet the requirements of the scientific community. As BioRep begins to create its own cell library, the combined contents of the Coriell-BioRep cryogenic repository will be the largest collection in the world.

BioRep will use cutting edge strategies to provide the following services.

Establishment of cell lines:

• EBV transformed lymphoblast cultures from human blood
• Fibroblasts, endothelial, smooth muscle and epithelial cell cultures from appropriate tissue biopsies
• Cryopreservation of Peripheral Whole Blood for Future DNA Isolation
• Cryopreservation of Isolated Lymphocytes from Blood (Buffy Coat)
• Establishment of a Fibroblast Large Scale Cell Culture from Tissues
• Establishment of a Fibroblast Small Scale Cell Culture from Tissue
• Establishment of a Large Scale Lymphoblast Cell Culture from Whole Blood
• Establishment of a Small Scale Lymphoblast Cell Culture from Whole Blood
• Trasformation of Cryopreserved Lymphocytes
• Trasformation of Cryopreserved Lymphocytes
• Viability Testing of Cell Cultures from an Outside Investigator
• Viability Testing of Cell Cultures in Inventory, Large Scale
• Viability Testing of Cryopreserved Lymphocytes (In-House, Trasformation)
• Viability Testing of Cryopreserved Lymphocytes from an Outside Investigator

Cell banking of public, private, or specialty collections:

• Expansion of cell lines for molecular and cytogenetic analysis
• Expansion of a Fibroblast Cell Culture for DNA Isolation
• Expansion of a Fibroblast Cell Culture for RNA Isolation
• Expansion of a Fibroblast Cell Culture for Frozen Cell Pellet
• Expansion of a Fibroblast Cell Culture from an Outside Investigator
• Expansion of a Lymphoblastoid Cell Culture for Seed Stock
• Preparing Plasma from Whole Blood

Remote Fail-Safe Storage:

• Cryopreservation of primary or transformed cell lines
• Cryopreservation of peripheral blood mononuclear cells (buffy coats)
• Preparation of Cryopreserved (Frozen) Cell Cultures of Buffy Coats for Shipment
• Cryopreservation of Blood products
• Other biomaterials