Huntington’s Disease (HD), first described by George Huntington in 1872, is a hereditary neurodegenerative disease that causes rapid cognitive decline, psychic behavioural problems and finally motor difficulties.

It is characterized by a more frequent onset in adulthood (between 30-45 years) but can occur at any age, from childhood to old age. The disease is caused by an autosomal dominant mutation in the gene responsible for the production of huntingtine, which carries a 50% risk of inheriting the disease if one of the two parents is affected.

The CAG triplet, which is repeated within the huntingtine gene, leads to a mutated form of huntingtine that gradually damages brain cells through mechanisms that are still unknown but on which research is focused today.